Australian Pet Nutrition PEA

✔PEA is a naturally occurring fatty acid amide which affects endocannabinoid signalling. PEA achieves its analgesic effects via indirect activation of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors; as well as indirect activation of PPAR-alpha, and several other receptors.

✔PEA has been explored since 1957 and has a clear analgesic and anti-inflammatory efficacy, and virtually no side effects. Meanwhile within the context of clinical trials 5000 patients have been using PEA, and its efficacy and safety has been documented in more than 500 scientific papers.

✔PEA is referred to as a natural painkiller and anti-inflammatory compound. PEA is produced in our cells and found in some foods.

✔PEA reduces the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and enzymes like COX-2 involved in inflammatory processes.

✔It down regulates mast cell activation, preventing the release of histamines and other inflammatory mediators.

✔PEA modulates the activity of glial cells in the nervous system. Overactivation of these cells contributes to neuropathic pain and chronic pain syndromes.

✔PEA has shown efficacy in managing various types of pain:

• Neuropathic Pain: Conditions like sciatica, diabetic neuropathy, and post-herpetic neuralgia.
• Inflammatory Pain: Arthritis, fibromyalgia, and musculoskeletal disorders.
• Visceral Pain: Conditions like endometriosis and interstitial cystitis.
• Chronic Pain Syndromes: Including complex regional pain syndrome (CRPS).